ESPU Congress 2017 - Abstract book

19–22 APRIL, 2017, BARCELONA, SPAIN

13:36–13:39

S1-3 (PP)

ANDROGEN RECEPTOR DISTRIBUTION ON VENTRAL

VERSUS DORSAL ASPECT OF CORPORAL BODIES

OF CHILDREN WITH CAH: COULD IT BE USED AS A MODEL

EXPLAINING RE-CURVATURE IN HYPOSPADIAS

CHILDREN?

Ashraf SAAD

, Haytham BADAWY

, Dina ABDALLAH

, Shaymaa ELSAYED

Doaa KHATER

and Magdy OMAR

1) University of Alexandria, Urology, Alexandria, EGYPT - 2) University of Alexandria, Ped-urology, Alexandria, EGYPT

- 3) University of Alexandria, Pathology department, Alexandria, EGYPT - 4) University of Alexandria, Endocrinology

department, Alexandria, EGYPT

PURPOSE

In this study we evaluated the distribution of the androgen receptors on the ventral and dorsal

aspects of the pathological corpora cavernosa to evaluate its role in the development and the pos-

sible redevelopment of penile curvature.

MATERIAL AND METHODS

Six patients with congenital adrenal hyperplasia, who were admitted for reduction clitoroplasty

between January 2014 and December 2015. The cases were considered as a model for the patho-

logical corpora cavernosa of sever hypospadias. The study protocol was approved by the Human

Ethics Review Committee of the hospital and assigned consent form was obtained from parents.

Whole surgically removed clitoris was processed. Immunohistological staining procedures and

evaluation of Androgen receptors was done. The immunoreactivity of androgen receptors was

evaluated according to the intensity and percentage of positively stained cells.

RESULTS

Androgen receptor expression was significantly more evident on the dorsal than the ventral surface

of the corpora cavernosa in the nuclei of vascular endothelia cells and stromal fibroblasts.

CONCLUSIONS

Unequal distribution of androgen receptors between the ventral and dorsal aspects of the corporal

tissues can be a cause of the development of penile curvature. Under-correction of these cases

during hypospadias repair can be a cause of the development of re-curvature with re-stimulation of

these receptors after puberty.