49 / 330
49
19–22 APRIL, 2017, BARCELONA, SPAIN
08:26–08:29
S4-3 (PP)
SURVEY OF HLA DISTRIBUTION IN PATIENTS WITH END
STAGE RENAL DISEASE SECONDARY TO REFLUX
NEPHROPATHY
Rahsan OZCAN
1
, Elif Altinay KIRLI EGEMEN
2
, ElIf KOTAN
2
, Salih PEKMEZCI
3
,
Nurhan SEYYAHI
4
, Erkan YILMAZ
5
, Nur CANPOLAT
6
, Mehmet Riza ALTIPARMAK
4
and Mehmet ELIÇEVIK
2
1) Istanbul University Cerrahpasa Medical Faculty, Pediatric Surgery, Pediatric Urology, Istanbul, TURKEY - 2) Istanbul
University Cerrahpasa Faculty of Medicine, Pediatric Surgery, Pediatric Urology, Istanbul, TURKEY - 3) Istanbul
University Cerrahpasa Faculty of Medicine, General Surgery, Istanbul, TURKEY - 4) Istanbul University Cerrahpasa
Faculty of Medicine, Internal Medicine, Division Of Nephrology, Istanbul, TURKEY - 5) Istanbul University Cerrahpasa
Faculty of Medicine, Transplantation, Istanbul, TURKEY - 6) Istanbul University Cerrahpasa Faculty of Medicine,
Pediatrics, Nephrology, Istanbul, TURKEY
PURPOSE
Vesicoureteral reflux (VUR) is a reason of chronic kidney disease. The factors that affecting the
development of end stage renal disease (ESRD) in reflux nephropathy (RN) are renal dysplasia/
hypoplasia/obstruction, recurrent urinary tract infections, bladder dysfunction and treatment mo-
dalities. Association of certain human leukocyte antigen (HLA) types with certain type of disease
is well known. The aim of this study is to evaluate the HLA types of patients who underwent renal
transplantation secondary to RN, in order to investigate for a significant association.
MATERIAL AND METHODS
This is a retrospective study. The VUR group consists of 26 patients (male: 15, female: 11) who
underwent renal transplantation for RN. Thirty-eight (male: 14 female: 24) healthy donors were
randomized in the control group. The HLA types were abstracted from the records. Chi-square test
was performed for statistical analysis and Odds ratio (OR) was calculated.
RESULTS
The median age was 25, 2 years (range 10-41) in VUR group and 43,9 years (range 20-76) in the
Control group. A statistically significant difference for HLA A and B types were not encountered.
HLA-DRB1*01 was significantly higher in the VUR group than the control group (p=0,024). The
Odds Ratio for HLA-DRB1*01 was 2,727. The risk of developing ESRD secondary to RN was
2,272 times higher in the presence of HLA-DRB1*01.
CONCLUSIONS
The association of HLA-DRB1*01 and end stage renal disease secondary to reflux nephropathy
was established in a limited number of patients.
08:29–08:38
Discussion