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28
TH
CONGRESS OF THE ESPU
S21-5 (P without presentation)
THE INFLUENCE OF COMPLIANCE ON THE THERAPEUTIC
EFFECTS OF MINIRIN IN MONOSYMPTOMATIC ENURESIS
TREATMENT
Sasa MILIVOJEVIC
1
and Zoran RADOJICIC
2
1) University Children’s Clinic Belgrade, Urology department, Belgrade, SERBIA - 2) University Children’s Clinic
Belgrade, Urology department, Belgrade, SERBIA
PURPOSE
To prove the importance of compliance on the therapeutic effects of Minirin in monosymptomatic
enuresis treatment.
MATERIAL AND METHODS
The research was carried out in the 2014-2016 period, during which 26 patients were observed who
were treated with Minirin due to the previously diagnosed monosymptomatic enuresis. The average
age of the patients was 8.8 years +/- 2.4 SD, out of whom 61.5% were boys and 38.5% girls. After
the 3-month Minirin treatment, the effect of medication therapy was compared with compliance.
Regarding compliance, the analysis encompassed regular drug intake, arbitrary discontinuation
of therapy, improper dosage, drug administration against the instructions, and not following advice
related to urination training, fluid intake in the evening, diet, irregular bowel movement, or not fol-
lowing the psychologist’s advice.
RESULTS
The average enuresis frequency before therapy was 23.3 per month +/- 5.4 SD, whereas the
average enuresis frequency after the therapy began was 10.6 per month +/- 8.7 SD. The t-test
application proved that there is a major statistical difference in enuresis frequencies before and after
Minirin treatment (p< 0.001). In the examined group, 16 patients did not demonstrate compliance,
while 10 patients demonstrated compliance. An average enuresis reduction in the group that did not
demonstrate compliance was 30.1% +/- 22.2 SD, while in the group that demonstrated compliance
it was 90.7% +/- 6.8 SD. The t-test application proved that there is a highly important statistical
difference between these two patient groups (p< 0.001).
CONCLUSIONS
Compliance considerably influences the beneficial effects of Minirin, because of which it is neces-
sary to prescribe it to each patient on Minirin treatment, especially to patients whose therapeutic
effects are poor.