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TH
CONGRESS OF THE ESPU
S21: NOCTURNAL ENURESIS
Moderators: Gillain Barker (Sweden), Erik Van Laecke (Belgium)
ESPU Meeting on Saturday 22, April 2017, 09:12–09:40
09:12–09:17
S21-1 (LO)
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TRANSCUTANEOUS ELECTRICAL NERVE STIMULATION
IN CHILDREN WITH MONOSYMPTOMATIC NOCTURNAL
ENURESIS: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-
CONTROLLED STUDY
Cecilie Voldum SIGGAARD, Konstantinos KAMPERIS, Luise BORCH, Britt BORG
and Søren RITTIG
Aarhus University Hospital, Pediatrics, Aarhus N, DENMARK
PURPOSE
Involuntary voiding during sleep, nocturnal enuresis (NE), affects 10-15% of all 7-year-olds and
0.5-2% of young adults. Approximately one-third of all children with NE are refractory to first line
treatments. Transcutaneous Electric Nerve Stimulation (TENS) has been documented efficacious
in children with daytime incontinence. The aim was to investigate the effect of TENS in children with
monosymptomatic nocturnal enuresis (MNE) without nocturnal polyuria.
MATERIAL AND METHODS
We performed a randomized, double-blind, placebo-controlled study. The children were randomized
to treatment with either active TENS or placebo TENS for one hour twice daily for ten weeks with
electrodes placed in the sacral region at the S2/S3 outflow.
RESULTS
In total, 52 children with MNE were included and 47 completed treatment (mean age 9.5 ± 2.1 years,
38 males). No children experienced full response with complete remission of enuresis whereas two
children, who received placebo treatment, showed partial response (≥50% reduction). TENS did
not lead to significant changes in the number of wet nights, nocturnal urine production on wet or dry
nights, maximum voided volume with and without first morning voided volume or voiding frequency
when comparing the parameters before and after treatment. There was no significant difference
between active and placebo TENS in any outcome variable.
CONCLUSIONS
The present study demonstrates no anti-enuretic effect of TENS in children with MNE without
nocturnal polyuria. Nocturnal urine production and bladder capacity characteristics remained
unchanged after treatment with TENS.