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28
TH
CONGRESS OF THE ESPU
08:48–08:51
S14-3 (PP)
THE EFFECT OF PREOPERATIVE TESTOSTERONE
ADMINISTRATION ON THE TESTIS IN PATIENTS
WITH HYPOSPADIAS
Michiko NAKAMURA, Kimihiko MORIYA, Yoko NISHIMURA, Yukiko KANNO,
Takeya KITTA, Masafumi KON and Nobuo SHINOHARA
Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Department of Renal and Genitourinary
Surgery, Sapporo, JAPAN
PURPOSE
Testosterone administration (TA) is often indicated before hypospadias (HS) surgery especially for
small penis. We retrospectively examined the changes of ultrasonographic findings on the testis
before and after TA to evaluate the effect of TA on the testes in patients with HS.
PATIENTS AND METHODS
Among patients with HS who were born during March 2010 and December 2014, children who
underwent ultrasonography before and after TA before HS surgery were enrolled. Total testicular
volume (TTV) and the incidence of testicular microlithiasis (TM) were compared before and after
TA. Statistical analysis was performed by Wilcoxon’s signed rank sum test and Fisher’s exact test.
P<0.05 was considered significant.
RESULTS
Thirty-eight patients (mild HS: 20, severe HS: 18) were included. TTV was unchanged after TA
among patients with mild and⁄or severe HS (table 1). TM was observed only in patients with severe
HS. TM was newly detected in 2. Accordingly, the incidence of TM was increased after TA (3 pa-
tients (4 testes) before TA and 5 patients (8 testes) after TA; table 2). TTV was not different between
patients with TM and without TM.
Table 1: Changes of TTV before and after TA
before TA
after TA
P value
TTV (mean ± SD)
0.81 ± 0.25 ml
0.81 ± 0.27 ml
0.989
Mild HS (n=20)
0.82 ± 0.28 ml
0.75 ± 0.29 ml
0.266
Severe HS (n=18)
0.79 ± 0.22 ml
0.87 ± 0.24 ml
0.133
Table 2: Incidence of TM before and after TA
before TA
after TA
Mild HS
Severe HS
Mild HS
Severe HS
TM(+)
0
3 pts (4 testes)
0
5 pts (8 testes)
CONCLUSIONS
While TAbefore HS surgery did not affect TTV, the incidence of TM increased in patients with severe
HS after TA. This finding suggests that TA before HS surgery might have negative impact on the
testis in some patients especially with severe HS.