Table of Contents Table of Contents
Previous Page  148 / 330 Next Page
Information
Show Menu
Previous Page 148 / 330 Next Page
Page Background

148

28

TH

CONGRESS OF THE ESPU

08:48–08:51

S14-3 (PP)

THE EFFECT OF PREOPERATIVE TESTOSTERONE

ADMINISTRATION ON THE TESTIS IN PATIENTS

WITH HYPOSPADIAS

Michiko NAKAMURA, Kimihiko MORIYA, Yoko NISHIMURA, Yukiko KANNO,

Takeya KITTA, Masafumi KON and Nobuo SHINOHARA

Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Department of Renal and Genitourinary

Surgery, Sapporo, JAPAN

PURPOSE

Testosterone administration (TA) is often indicated before hypospadias (HS) surgery especially for

small penis. We retrospectively examined the changes of ultrasonographic findings on the testis

before and after TA to evaluate the effect of TA on the testes in patients with HS.

PATIENTS AND METHODS

Among patients with HS who were born during March 2010 and December 2014, children who

underwent ultrasonography before and after TA before HS surgery were enrolled. Total testicular

volume (TTV) and the incidence of testicular microlithiasis (TM) were compared before and after

TA. Statistical analysis was performed by Wilcoxon’s signed rank sum test and Fisher’s exact test.

P<0.05 was considered significant.

RESULTS

Thirty-eight patients (mild HS: 20, severe HS: 18) were included. TTV was unchanged after TA

among patients with mild and⁄or severe HS (table 1). TM was observed only in patients with severe

HS. TM was newly detected in 2. Accordingly, the incidence of TM was increased after TA (3 pa-

tients (4 testes) before TA and 5 patients (8 testes) after TA; table 2). TTV was not different between

patients with TM and without TM.

Table 1: Changes of TTV before and after TA

before TA

after TA

P value

TTV (mean ± SD)

0.81 ± 0.25 ml

0.81 ± 0.27 ml

0.989

Mild HS (n=20)

0.82 ± 0.28 ml

0.75 ± 0.29 ml

0.266

Severe HS (n=18)

0.79 ± 0.22 ml

0.87 ± 0.24 ml

0.133

Table 2: Incidence of TM before and after TA

before TA

after TA

Mild HS

Severe HS

Mild HS

Severe HS

TM(+)

0

3 pts (4 testes)

0

5 pts (8 testes)

CONCLUSIONS

While TAbefore HS surgery did not affect TTV, the incidence of TM increased in patients with severe

HS after TA. This finding suggests that TA before HS surgery might have negative impact on the

testis in some patients especially with severe HS.