147 / 330
147
19–22 APRIL, 2017, BARCELONA, SPAIN
08:45–08:48
S14-2 (PP)
THE EFFECT OF PREOPERATIVE HORMONAL
STIMULATION ON OPERATIVE OUTCOMES AFTER
PROXIMAL HYPOSPADIAS REPAIR
Mariela DORE
1
, Paloma TRIANA
1
, Virgina AMESTY
2
, Vanessa NÚÑEZ
1
,
Roberto LOBATO
2
, Susana RIVAS
2
, Pedro LOPEZ PEREIRA
2
and Maria
Jose MARTÍNEZ-URRUTIA
2
1) Children’s Hospital La Paz, Pediatric Surgery, Madrid, SPAIN - 2) Children’s Hospital La Paz, Pediatric Urology,
Madrid, SPAIN
PURPOSE
Hormonal stimulation prior to hypospadias repair remains controversial. Our aim was to evaluate
the impact of pre-operative hormone stimulation (PHS) treatment on complication rates of proximal
hypospadias repair.
MATERIAL AND METHODS
Single-center retrospective study of patients with penoscrotal hypospadias repaired using a tubular-
ized preputial flap as primary technique from 2000 to 2010. Patients were divided into two groups
according to whether or not they received PHS >3 months prior to repair. The decision to provide
PHS was made under the surgeon´s assessment. Charts were reviewed for surgical complications
associated healing failure and PHS: suture dehiscence, fistulae and meatal stenosis.
RESULTS
A total of 60 patients underwent a tabularized preputial flap as a primary repair at 36±8 months of
age with follow-up of 8±1.25 years. PHS was indicated in of 64% (n=38) with a median of 3 (1-5)
doses of intramuscular testosterone (25mg). The global complication rate for proximal hypospadias
repair was 52%. A lower complication rate was observed in the PHS group 45% versus 65% in the
non-PHS, however the difference was not statistically significant (p>0,05). Univariate analysis of the
dehiscence, urinary fistulae, or meatal stenosis yielded complications rates of 0%, 42% and 10%
respectively in the PHS group, versus 4,5%, 64% and 9% In the non-PHS group (p>0,05). During
follow-up 25% reached puberty with only 10% of patient loss.
CONCLUSIONS
Results from this study suggest that PHS prior to proximal hypospadias repair did not affect the
complication rate due to healing failure. Future prospective studies are needed to assure the indica-
tion of PHS.