ESPU Congress 2017 - Abstract book

198

CONGRESS OF THE ESPU

16:03–16:06

S18-2 (PP)

PROGNOSTIC SIGNIFICANCE OF MATERNAL URINARY

CARBOHYDRATE ANTIGEN 19-9 FOR ANTENATAL

DIAGNOSIS OF POSTERIOR URETHRAL VALVE

ASSOCIATED WITH FETAL HYDRONEPHROSIS

Abdol-Mohammad KAJBAFZADEH

, Shabnam SABETKISH

and Nastaran SABETKISH

1) Tehran University of Medical Sciences, Pediatric Urology and Regenerative Medicine Research Center, Pediatric

Center of Excellence, Tehran, ISLAMIC REPUBLIC OF IRAN - 2) Tehran University of Medical Sciences, Pediatric

Urology and Regenerative Medicine Research Center, Pediatric Center of Excellence, Tehran, ISLAMIC REPUBLIC

OF IRAN

PURPOSE

To evaluate the predictive role of maternal urinary CA 19-9 as a non-invasive marker for diagnosing

antenatal posterior urethral valve (PUV).

MATERIAL AND METHODS

A total of 40 women in the third pregnancy trimester were enrolled. Case group (group A) consisted

of 20 women with a diagnosis of antenatal PUV. An anteroposterior diameter (APD)≥15 confirmed

severe hydronephrosis. Twenty women with similar gestational age, fetal sex, normal US, and no

history of congenital anomalies were chosen as control group (group B). Maternal urine samples

were collected and urinary CA 19-9 was measured in both groups. The correlations between mater-

nal urinary CA 19-9 and APD (measured during pregnancy and the initial evaluation of the newborn)

were assessed. CA 19-9 level in first urine of neonates was also evaluated.

RESULTS

In GroupA, theAPD ranged from 18 to 38 in twelve cases. Eight cases had contralateral APD≥9 mm.

The mean±SD of maternal urine CA 19-9 was higher in PUV group compared to control group

(731.6±53.8 U/mL vs. 13±2.7 U/mL). In addition, there was a significant correlations between

maternal urinary CA 19-9 and the APD measured at the third trimester (p=0.02) and the initial

evaluation of fetus after birth according to SFU grading system (p<0.001). However, no significant

difference was found regarding gestational age and urinary CA 19-9 level (p=0.34). There was

also a significant correlation between CA 19-9 level in first urine of neonates with CA 19-9 level of

maternal urine (p<0.05).

CONCLUSIONS

This is the first time that maternal urinary CA 19-9 has been applied as a diagnostic marker in

antenatal PUV. Urinary CA 19-9 is higher in the urine of pregnant women carrying fetus with PUV

and it may have the potential to serve as a noninvasive and practical method for diagnosing PUV.