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CONGRESS OF THE ESPU
13:40–13:43
S16-3 (PP)
★
STUDY OF TESTICULAR FUNCTION IN INFANTS
AND CHILDREN WITH ATYPICAL GENITALIA DUE
TO DISORDER OF SEX DEVELOPMENT (46, XY DSD)
Shaymaa RAAFAT
1
, Haytham BADAWY
2
, Doaa KHATER
1
, Shaymaa ELSAYED
1
and Magdy OMAR
1
1) University of Alexandria, Endocrinology department, Alexandria, EGYPT - 2) University of Alexandria, Ped-urology,
Alexandria, EGYPT
PURPOSE
to evaluate the role of serum AMH as a new tool for investigating the function of the pre-pubertal
testis without the need for HCG stimulation test, and to compare the value of basal inhibin B with
testosterone response after HCG stimulation in the prediction of pre-pubertal testicular function.
MATERIAL AND METHODS
we studied 33 cases ranging in age from 1 month to 15 years through a whole year from 10/2015 to
10/ 2016. The patients had been referred for hormonal evaluation of gonadal function, including
basal testosterone, FSH, LH, AMH, and inhibin B and HCG stimulation test.
RESULTS
we found that there were 16 cases with 5 alpha reductase type2 deficiencies, 10 cases with partial
androgen insensitivity, 2 cases with complete androgen insensitivity, 3 cases with syndromic XY
DSD, one case with bilateral vanishing testes and one case with partial gonadal dysgenesis. There
is clear correlation between basal inhibin B and testosterone increment after HCG stimulation (this
was clearly shown in 27 cases in the study). In cases with vanishing testes and gonadal dysgenesis,
there was no detectable respectable normal level of inhibin B and AMH. That finding may highlight
the role of AMH and inhibin B in assessment of XY DSD cases. There was significant correla-
tion between AMH and inhibin B. There was a stronger correlation between serum FSH level and
primarygonadal failure rather than using basal inhibin B in such correlation.
CONCLUSIONS
Basal AMH, inhibin B and FSH are valuable tools during testicular function assessment in cases
with XY DSD.
13:43–13:52
Discussion