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19–22 APRIL, 2017, BARCELONA, SPAIN
MATERIAL AND METHODS
We conducted a prospective study of all patients undergoing single or staged hypospadias repairs
over a one-year period (2015-2016). The repair was performed over a feeding tube and either
a silastic foam (Cavicare) or gauze dressing applied, according to surgeon preference. Carers
completed a questionnaire at one week to assess for incidence of bladder spasms, level of post-
operative pain on day 1 and 7, analgesic requirement and post-operative problems or hospital
attendance. The cost of each dressing was calculated by working out the sum of the individual
dressing components and preparation time.
RESULTS
41 out of 45 patients completed the questionnaire. The incidence of bladder spasms (p=0.31) and
the level of post-operative pain on day 1 (p=0.13) and 7 (p=0.72) did not differ significantly between
the two dressing groups. The frequency of post-operative problems (p=0.75) or attendance to the
hospital (p=0.97) was not significantly different between the two dressing groups. Twenty-six pa-
tients were discharged home the day of surgery. The foam dressing was three times as expensive
as the simple gauze dressing.
CONCLUSIONS
Within the limitation of patient numbers, the simple gauze dressing was as effective as the more
expensive alternative. The study also showed that same-day discharge is a safe option for these
patients, and that analgesia is only required for the first few post-operative days.
12:14–12:17
S8-7 (PP)
ANTENATAL PREVENTIVE EFFECT OF MEDICATIONS
DURING PREGNACY IN PATIENTS WITH HYPOSPADIAS:
CASE-CONTROL ANALYSIS IN 24-YEARS IN SOUTH
AMERICA
Nicolas FERNANDEZ
1
, Angie PUERTO
2
, Darius BAGLI
1
, Armando LORENZO
1
and Ignacio ZARANTE
3
1) Hospital for SickKids, Urology, Toronto, CANADA - 2) Hospital Universitario San Ignacio, Human Genetics Institute,
Bogota, COLOMBIA - 3) Pontificia Universidad Javeriana, Human Genetics Institute, Bogota, COLOMBIA
PURPOSE
Environmental risk factors have been described in association with hypospadias. Recent geographi-
cal cluster analysis shows predisposing regions with high or low prevalence rates of hypospadias
in South-America (SA). Multiple studies focus on deleterious effects of endocrine disruptors but
few have focused on environmental protective factors. Effect of folic acid multivitamins reducing
hypospadias prevalence might explain specific geographic distributions. The present study explores
potential association of medications exposure during pregnancy and hypospadias.
MATERIAL AND METHODS
Case control analysis from 1982 - 2011 in SAanalyzing exposure to different medications in patients
with hypospadias. The Latin American collaborative study of congenital anomalies (ECLAMC)
database was used. Cases were all newborns hypospadias and controls healthy newborns without
congenital malformations. Analyzed variables included exposure of medications by trimesters for
cases and controls.