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19–22 APRIL, 2017, BARCELONA, SPAIN
08:39–08:42
S20-6 (PP)
★
ARE URINARY NEURAL GROWTH FACTOR (NGF)
AND BRAIN DERIVED GROWTH FACTOR (BDNF)
VALUABLE BIOMARKERS IN THE DIFFERENTIAL
DIAGNOSIS OF IDIOPATHIC AND SECONDARY
OVERACTIVE BLADDER
Can TANELI
1
, Hasan CAYIRLI
2
, Fatma TANELI
3
, Pelin ERTAN
4
, Ipek AKIL
4
and Raziye YILDIZ
3
1) Celal Bayar University,Faculty of Medicine, Department of Paediatric Surgery & Paediatric Urology, Manisa,
TURKEY - 2) Celal Bayar University, Faculty of Medicine, Department of Paediatric Surgery, Division of Paediatric
Urology, Manisa, TURKEY - 3) Celal Bayar University, Faculty of Medicine, Department of Clinical Biochemistry, Manisa,
TURKEY - 4) Celal Bayar University, Faculty of Medicine, Department of Paediatrics, Division of Paediatric Nephrology,
Manisa, TURKEY
PURPOSE
Urinary neural growth factor (NGF) and brain derived growth factor (BDNF) are novel biomark-
ers in the diagnosis and assessment of overactive bladder (OAB). The aim of the present study
is to investigate urinary NGF and BDNF in idiopathic OAB and overactive bladder secondary to
dysfunctional voiding.
MATERIAL AND METHODS
Twenty-seven children with lower urinary tract dysfunction (study group) and 20 healthy children
(control group) were recruited in this prospective study. In the study group patients were subgrouped
as; Group1:idiopathic OAB(n=10), group 2: dysfunctional voiding and secondary OAB(n=10), group
3:dysfunctional voiding(n=7). NGF, BDNF and creatinine(Cr), tests were assessed in urine samples.
BDNF and NGF values were normalized with urinary creatinine concentrations.
RESULTS
Urinary NGF/Cr was not statistically significant between the study groups and the control group.
Urinary NGF/Cr was significantly (p=0.026) higher only in the comparison of the combined idiopathic
OAB and secondary OAB (group 1+group2, n=20) group compared to the healthy controls and
the sensitivity and specificity were 60% and 65%, respectively. Urinary BDNF/Cr was significantly
higher in all study groups compared to the healthy controls (Group 1 vs control group p=0.0001,
group 2 vs control group p=0.0001, group 3 vs control group p=0.041). Sensitivity and specificity
of BDNF/Cr were found %95 and %90, respectively. Urinary BDNF/Cr was significantly (p=0.001)
higher in combined idiopathic OAB and secondary OAB (group 1+group2, n=20) group compared
to the healthy controls.
CONCLUSIONS
Due to the heterogeneous character of the etiology of overactive bladder, urinary NGF/Cr and BDNF/
Cr are not specific biomarkers to differentiate the idiopathic OAB from secondary OAB patients.