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TH
CONGRESS OF THE ESPU
16:35–16:38
S11-8 (PP)
ALPHA-BLOCKER THERAPY FOR BOYS UNDER
12 MONTHS OF AGE AFTER ENDOSCOPIC INCISION
OF POSTERIOR URETHRAL VALVES AND BLADDER NECK
Gabriela GROCHOWSKA, Piotr GASTOL, Lidia SKOBEJKO-WLODARSKA
and Malgorzata BAKA-OSTROWSKA
Children’s Memorial Health Institute, Warsaw/Poland, Pediatric Urology, Warsaw, POLAND
PURPOSE
The aim of this study is to evaluate incidence of urinary tract infections (UTI’s), ultrasound examina-
tion (USG), leak point (LP) and post-void residual volume (PVR) in boys younger than 12 months,
before and 3 months after endoscopic incision of posterior urethral valves (PUV) and bladder neck
(BN), according to alpha-blocker therapy.
MATERIAL AND METHODS
The prospective study included 44 boys from 3 days to 12 months of age (median 3 months) with
PUV and severe BN hypertrophy (white/rigid/high), treated with transurethral incision (TUI) of PUV
and BN at the same procedure.
Patients were divided into:
Group A - 22 without alpha-blocker therapy.
Group B - 22 with alpha-blocker therapy (doxazosin 0,5 mg/day).
UTI, USG, LP and PVR were checked before and 3 months after TUI.
RESULTS
No difference in incidence of UTI’s between Group A (before TUI 5/22, after 2/22) and B (before TUI
7/22, after 5/22).
Renal pelvis and ureter diameters in USG decreased in both groups.
Changes of LP shows Tab. 1:
LP
(cm H20)
40-80
81-120
121-160
>160
TUI
Before After
Before After
Before After
Before After
Group A 5
8
9
8
6
4
2
2
Group B 6
11
7
10
5
1
4
0
PVR in Group A occurred in 12/22 before TUI and 11/22 after, in Group B 17/22 before and
16/22 after.
CONCLUSIONS
1. TUI of PUV and BN with alpha-blocker therapy appears to be effective to decrease the LP in
boys under 12 moths of age.
2. Further investigation are needed to evaluate the advantages of low LP in infants with history of
PUV and BN hypertrophy in long-term follow-up.