ESPU Congress 2018 - Abstract Book

89 11–14 APRIL, 2018, HELSINKI, FINLAND 14:46–14:49 S10-3 (PP) ★ TOTAL MOTILE COUNT (TMC) INCREASES WITH AGE IN ADOLESCENT VARICOCELE PATIENTS; SPERM CONCENTRATION IS AN AGE INDEPENDENT PARAMETER David KEENE and Raimondo CERVELLIONE Royal Manchester Children's Hospital, Department of Paediatric Urology, Manchester, UNITED KINGDOM PURPOSE Total motile count (TMC) has been reported recently to improve overtime with conservative and surgically managed varicocele patients 14.8–21.8 years. The aim of this study is to identify if TMC is correlated with age and can be reliably used to assess changing in fertility in adolescent varicocele patients. MATERIAL AND METHODS Data was prospectively collected from a single institution from 2009 to 2017. All post-pubertal vari- cocele patients aged 12 to 18 years who successfully produced semen samples by masturbation were included. Sperm parameters were recorded, TMC calculated and data presented as median (IQ range). The correlation with age was analysed using Kendall’s rank correlation and 2-sided confidence intervals, p<0.05 was considered significant. RESULTS 135 sperm samples were analysed from 109 adolescent patients (17 visible and 92 palpable left sided varicoceles). Median patient age was 15.9 years (15.0–17.1). The following subgroups were identified: Group A (72 samples) symmetrical testicular volumes managed conservatively Group B (9 samples) asymmetrical testicular volumes awaiting surgery Group C (29 samples) undergone surgery for asymmetrical testicular volumes Group D (25 samples) undergone surgery for pain Parameter Median (Interquartile range) Kendal’s rank Correlation coefficient (r) P value 2-sided confidence interval P value sub-group analysis Semen volume (mls) 1.9 (1.0-3.4) 0.24 <0.0001* 0.0002* (Group A) Total motile count (mls) 27.5 (5.5-56.0) 0.24 <0.0001* 0.007* (Group A) 0.03* (Group A) Concentration (millions/ml) 31.0 (10.2-56.0) 0.10 0.09 Forward motility (%) 50 (35-50.5) 0.11 0.06 0.02* (Group C) *p<0.05 The semen volume and total motile count was significantly correlated with age in the overall and sub group analysis. CONCLUSIONS TMC increases with age in the adolescent period and therefore cannot be reliably interpreted in adolescent varicocele patients. Sperm concentration and forward motility should be used instead. 14:49–14:58 Discussion