ESPU Congress 2018 - Abstract Book

63 11–14 APRIL, 2018, HELSINKI, FINLAND 09:39–09:42 S6-2 (PP) ROLE OF URINARY BIOMARKERS IN CORRELATION TO DIURETIC RENOGRAM IN CHILDREN WITH URETERO- PELVIC JUNCTION OBSTRUCTION UNDERGOING PYELOPLASTY Waleed DAWOOD  1 , Haitham BADAWY  2 , Samir ORABI  2 , Ahmed FAHMY  2 , Mohamed YOUSSEF  2 , Reham ABDELHALEEM  3 and Mohamed ABDELRAZEK  2 1) Alexandria faculty of Medicine, Faculty of Medicine, Alexandria, EGYPT - 2) ALEXANDRIA UNIVERSITY, UROLOGY, Alexandria, EGYPT - 3) ALEXANDRIA UNIVERSITY, CILINICAL PATHOLOGY, Alexandria, EGYPT PURPOSE Urinary biomarkers as KIM and NGAL could be used as predictors for structural and functional kidney damage resulting from UPJO, thus can replace diuretic renogram. Our study was to cor- relate urinary KIM and NGAL levels pre and postoperatively and with the DRF of the affected kidney. MATERIAL AND METHODS A prospective controlled study was done in 30 patients treated with unilateral dismembered py- eloplasty from 2016 to 2017. Urine samples were obtained preoperatively, intraoperatively, and 6 months postoperatively. A control group consist of 10 healthy children. RESULTS There was an increase in uKIM and uNGAL levels in pre and intraoperative urine samples (4.85 ng/ ml, 5.40 ng/ml for NGAL, 0.32 ng/ml, 0.38 ng/ml for KIM), a significant reduction in these levels was found after surgical repair of UPJO (1.5 ng/ml for NGAL, 0.09 ng/ml for KIM), these high levels preoperatively don't significantly correlate with the DRF, also these levels preoperatively was signifi- cantly higher than that from control group concerning uNGAL (0.60 ng/ml) but insignificantly higher than that from control group concerning uKIM (0.20 ng/ml). CONCLUSIONS Preoperative uKIM-1and uNGAL levels were increased significantly in patients with UPJO undergo- ing pyeloplasty, these high levels don't significantly correlates with diuretic renogram, and also there was a significant reduction in their concentrations in the postoperative follow-up. 09:42–09:45 S6-3 (PP) POSSIBLE PREDICTIVE FACTORS FOR A SAFE PRENATAL FOLLOW-UP OF FETUSES WITH HYDONEPHROSIS Abdurrahman ONEN Onen Cocuk Urolojisi Merkezi, Paediatric Surgery, Diyarbakir, TURKEY PURPOSE Introduction: To determine the factors affecting the resolution of hydronephrosis, create a follow-up protocol to predict the probability of pre-and/or postnatal resolution, and to refine criteria for a safe follow-up of fetuses with hydronephrosis.