ESPU Congress 2018 - Abstract Book

10 29 th CONGRESS OF THE ESPU S1: BASIC RESEARCH 1 Moderators: Yazan Rawashdeh (Denmark), Christian Radmayr (Austria) ESPU Meeting on Wednesday 11, April 2018, 13:30–15:00 13:30–13:33 S1-1 (PP) ★ HISTOLOGIC FEATURES OF THE EXSTROPHIC BLADDER BEFORE AND AFTER DELAYED PRIMARY REPAIR: RESULTS OF AN ONGOING PROSPECTIVE STUDY Peter RUBENWOLF  1 , Fabian EDER  2 , Stefanie GOETZ  3 , Anne-Karoline EBERT  4 and Wolfgang H. ROESCH  4 1) University Hospital Frankfurt, Urology, Frankfurt, GERMANY - 2) University Hospital Regensburg, Pathology, Regensburg, GERMANY - 3) University Hospital Regensburg, Urology, Regensburg, GERMANY - 4) University Hospital Regensburg, Pediatric Urology, Regensburg, GERMANY PURPOSE To investigate the exstrophic bladder at the time of primary bladder closure and subsequently during secondary procedures in view of histologic alterations and discuss the findings in terms of potential clinical implications. MATERIAL AND METHODS At least 2 bladder biospies from patients with classic BE were obtained a) at the time of delayed primary repair, b) during secondary reconstructive procedures and c) during subtotal cystectomy for failed reconstruction. Specimens were examined by a uropathologist for edema, fibrosis, inflamma- tory, metaplastic and proliferative changes. RESULTS As yet bladder specimens from 97 patients (mean age 6,4, range: 0,11–25 years) were analysed. Edema, fibrosis, inflammatory and proliferative changes were observed in all 3 groups. Dysplastic or malignant changes were not present. Detailed results are shown in Table 1. GROUP/Number of pts/ mean age Histologic feature (%) A - Primary delayed closure n=45; 0,17 yrs. B - Secondary procedures n=37; 7,8 yrs C - Cystectomy (failed reconstruction) n=15; 11,1 yrs Edema 55 40 20 Fibrosis 48 69 73 Inflammation 95 43 80 Squamous metaplasia 80 43 73 Cystitis cystica/glandularis 83 57 87 Intestinal metaplasia 0 14 53 Dysplasia/malignant neoplasia 0 0 0