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11–14 APRIL, 2018, HELSINKI, FINLAND
MATERIAL AND METHODS
A prospective, randomized, placebo-controlled, double-blind parallel trial was conducted. Between
2011 and 2015, in 4 French centers, one-stage Transverse Preputial Island Flap Urethroplasty
(Onlay urethroplasty) was proposed for severe hypospadias (i.e. midshaft or more proximal division
of the corpus spongiosum). Promestriene or placebo were applied daily on the penis for 2 months
before surgery.
The primary outcome was the presence of postoperative urethral fistula or dehiscence during the
first year after surgery. Detailed hormonal and anatomical screenings were performed.
RESULTS
The study kept 122 cases in the placebo arm and 119 cases in the Promestriene arm. The primary
outcome was unavailable for 11 patients. Healing complications were 16.4 % in the placebo arm
(19/116) vs. 14.9 % in the Promestriene arm (17/114) and the adjusted odds ratio (odd Promestriene
arm/odd Placebo arm) was 0.93 (p=0.86).
CONCLUSIONS
Although there is an overall drop of complications compared to previous publications from our
group, the results of both arms are not statistically different. This can be due either to a lack of
power of this study i.e. an insufficient number of cases in each group, or to an absence of benefit
from Promestriene over placebo.
Promestriene was provided by former Theramex, now Teva Pharmaceutical Industries Ltd.
10:55–10:58
S7-2 (PP)
★
SCROTAL BASE DISTANCE; A NEW KEY GENITAL
MEASUREMENT IN MALES WITH HYPOSPADIAS
AND CRYPTORCHIDISM
Tariq Osman ABBAS
1
, Mansour ALI
2
and Abdelrahman ELKADHI
2
1) Hamad General Hospital, Pediatric Surgery, Doha, QATAR - 2) Hamad Medical Corporation, Pediatric Surgery
Department, Doha, QATAR
PURPOSE
Anogenital distance (AGD) in animals and humans is a known biomarker of fetal endocrine disrup-
tion and the associated testicular dysgenesis syndrome (TDS). However, we introduce and inves-
tigate Scrotal Base Distance (SBD) as a sensitive genital anthropometric criterion in human infants
with cryptorchidism and hypospadias, which are potential manifestations of TDS during childhood.
We aim to compare SBD in boys with cryptorchidism or hypospadias against normative data.
MATERIAL AND METHODS
Boys with isolated cryptorchidism (n = 51, age 11.4 ± 4.8 months) or hypospadias (n = 61, age
17.4 ± 6.3 months) were recruited from a tertiary center for measurement of SBD, AGD and penile
length; they were compared with 102 healthy full-term boys from standard ritual circumcision cohort
by deriving age-specific standard deviation scores (SDS).
RESULTS
Boys with hypospadias had shorter mean SBD, AGD and penile length SDS than healthy boys
(both p < 0.001). Mean SBD, AGD and penile length SDS values in boys with cryptorchidism were
longer than mean values in boys with hypospadias (both p < 0.01) and shorter than mean values in
healthy boys (both p < 0.0001). Mean penile length SDS decreased as the severity of hypospadias
increased (ptrend = 0.078).