ESPU Congress 2018 - Abstract Book

11–14 APRIL, 2018, HELSINKI, FINLAND

15:53–15:56

S3-7 (PP)

EFFICIENCY OF HORMONE STIMULATION TREATMENT

BEFORE HYPOSPADIAS SURGERY: EXPERIMENTAL STUDY

Ozlem COLOGLU

, Murat ALKAN

, Emine Bagir KILIC

and Seyda ERDOGAN

1) Cukurova University, Paediatric Surgery, Adana, TURKEY - 2) Cukurova University, Pathology, Adana, TURKEY

PURPOSE

In hypospadias surgery, there is no consensus on the choice of hormone preparations, treatment

period and surgical timing. The purpose of this study is to observe structural and histopathologi-

cal changes of hormone stimulation therapy methods in the healthy (without hypospadias) animal

model and evaluate the ideal surgical time period after hormone stimulation.

MATERIAL AND METHODS

50 Wistar Albino rats, 4–6 weeks old, were used. Rats were divided into 5 groups as parenteral

human chorionic gonadotropin (hCG) group, parenteral testosterone (pT) group, topical dihydrotes-

tosterone (tT) group, and control groups of parenteral and topical treatment groups. Penis diameter

and length were measured throughout the study and after the application. Biopsies were taken from

preputium for histopathological examinations and evaluated for vascularity, epithelial thickness,

inflammation and fibrosis.

RESULTS

Increase of 56 %, 58 %, 84 % in penile length, 62 %, 59.8 %, 109 % in penile diameter, 46 %,

59 %, 100 % in number of vessels, observed in the group of hCG, pT and tT, respectively, of which

statistically significant when compared to the control groups. The optimum time for surgical repair

starting from the end of hormone administration was found as after the 4

, 6

and 1

week in hCG,

pT, and tT groups, respectively.

CONCLUSIONS

This study has shown that human chorionic gonadotropin, parenteral testosterone and topical

dihydrotestosterone treatments are useful in increasing penile size and tissue quality before hy-

pospadias surgery. The ideal surgical time period is; 4

, 6

and 1

week after the administration of

hCG, pT, and tT, respectively.

15:56–16:17

Discussion