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11–14 APRIL, 2018, HELSINKI, FINLAND
15:47–15:50
S3-5 (PP)
★
ISOLATED HYPOSPADIAS: IMPACT OF PRENATAL
EXPOSURE TO PESTICIDES DETERMINED BY MECONIUM
ANALYSIS
Elodie HARAUX
1
, Pierre TOURNEUX
2
, Erwan STEPHAN-BLANCHARD
3
,
Bernard BOUDAILLIEZ
4
and Karen CHARDON
5
1) CHU Amiens, Pediatric surgery, Amiens, FRANCE - 2) CHU Amiens, Department of Pediatric intensive care unit,
Amiens, FRANCE - 3) Jules Verne University of Picardy PeriTox - UMI 01, PeriTox - UMI 01, Amiens, FRANCE - 4) CHU
Amiens, Department of paediatrics, Amiens, FRANCE - 5) Jules Verne University of Picardy, PeriTox - UMI 01, Amiens,
FRANCE
PURPOSE
Although pesticides are suspected to increase the risk of hypospadias, none has been identified
in human studies. We aimed to investigate whether prenatal exposure to pesticides detected in
meconium constitutes a risk factor for isolated hypospadias (IH).
MATERIAL AND METHODS
In a case-control study, newborns with isolated hypospadias (n=32) matched with controls (n=90)
were included (2011–2014) at birth. We focused on a selective population with no genetic or hor-
monal abnormalities, no syndrome, or any other abnormality of the genitalia. Maternal exposure
was assessed by a questionnaire and a job-exposure matrix to endocrine-disrupting chemicals
(EDCs). Fetal impregnation was assessed by the meconium concentrations of the 11 pesticides or
metabolites (organophosphates, carbamates, phenylurea and phenoxyherbicides) commonly used
in this region.
RESULTS
Maternal occupational exposure to EDCs and the domestic use of hair cosmetics were identified
as exposure risk factors of IH (OR 3.94 (1.12–13.86) and 3.29 (1.22–8.85) respectively. The
pesticides most commonly detected in meconium were organophosphates (in 24.2 % to 98.9 % of
cases, depending on the substance) and phenylurea (> 86.8 %). Multivariate analysis showed an
association between IH and the presence of 2 pesticides in meconium: MCPA, a phenoxyherbicide
(OR 4.31 (1.22–15.20)) and isoproturon, a phenylurea (3.70 (1.06–12.84).
CONCLUSIONS
This study suggests the impact of multiple prenatal exposures to EDCs on the occurrence of IH
such as those found in cosmetics and in pesticides. Prenatal impregnation to phenoxyherbicides
and phenyluea assessed by meconium analysis was correlated with isolated hypospadias. These
findings support prevention messages for pregnant women concerning exposure to pesticides.