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11–14 APRIL, 2018, HELSINKI, FINLAND
S22: LOWER URINARY TRACT 2
Moderators: Gundela Holmdahl (Sweden), Abraham Cherian (UK)
ESPU Meeting on Saturday 14, April 2018, 09:10–09:54
09:10–09:13
S22-1 (PP)
★
THERAPEUTIC EFFECTS OF MINIRIN
IN MONOSYMPTOMATIC ENURESIS TREATMENT
DEPENDING ON PATIENTS' AGE
Sasa MILIVOJEVIC
1
, Jelena MILIN LAZOVIC
2
and Zoran RADOJICIC
3
1) University Children's Hospital Belgrade, Paediatric Surgery, Belgrade, SERBIA - 2) Faculty of Medicine, University
of Belgrade, Institute for Medical Statistics and Informatics, Belgrade, SERBIA - 3) University Children's Hospital
Belgrade, Paediatric Urology, Belgrade, SERBIA
PURPOSE
To test the therapeutic effects of Minirin in monosymptomatic enuresis treatment depending on
patients’ age.
MATERIAL AND METHODS
The prospective research was carried out in the 2014–2017 period, during which 89 patients were
observed who were treated with Minirin due to the previously diagnosed monosymptomatic enu-
resis. The patients were divided into two age groups. The first group consisted of 43 patients age
5 to 7, with the average age of 5.6 ± 0.5, out of whom 35 (81.4 %) were boys, and 8 (18.6 %) were
girls. The second group consisted of 46 patients age over 7 to 12, with the average age of 9.7 ± 1.6,
out of whom 30 (65.2 %) were boys, and 16 (34.8 %) were girls. There was no statistically relevant
difference according to sex (p=0.086). After the 3-month treatment, all the patients in both groups
were tested for the effects of Minirin in monosymptomatic enuresis treatment.
RESULTS
The average enuresis frequency in the first group before therapy was 26.0 ± 6.2 per month, whereas
the average enuresis frequency after therapy was 11.0 ± 8.0 per month (p=0.040). The average
enuresis frequency in the second group before therapy was 23.1 ± 6.2 per month, whereas the
average enuresis frequency after therapy was 3.8 ± 3.6 per month (p=0.036). ANOVA data analysis
of repeated measurements has indicated that there is a statistically relevant interaction between
the groups (p=0.006), i.e. enuresis frequency decreases considerably more in the second group.
CONCLUSIONS
Monosymptomatic enuresis treatment with Minirin is noticeably more effective with patients over
7 years of age.