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145
11–14 APRIL, 2018, HELSINKI, FINLAND
MATERIAL AND METHODS
A retrospective study of 41 patients diagnosed with PUV from 1984 to 2000 with mean follow-up
time of 20 years (33–17 years) was performed. Family history, prenatal diagnosis, ultrasound find-
ings, treatment, creatinine and nadir glomerular filtration and presence of VUR were assessed.
We reviewed the evolution and appearance of postoperative complications, infections, need for
reintervention, presence of lower urinary tract dysfunction, worsening renal function and need for
renal transplantation. These results were compared with the urinary clinic and the need for substitu-
tion treatment (Pearson's χ² test).
RESULTS
11 patients (35 %) presented parameters of renal failure at diagnosis; creatinine nadir of 1.71 mg
/ dl (1.1–3 mg / dL) and glomerular filtration of 59 mL / min / 1.73 m2 (50–95 mL/ min / 1.73 m2).
Of these, 70 % required renal transplantation. We found a positive association between creatinine
nadir> 1 mg / dL and the need for transplantation (p <0.001).
45 % of patients had lower urinary tract dysfunction. Lower urinary tract dysfunction and the pres-
ence of vesicourethral reflux were risk factors for renal failure (p <0.001).
We did not find significant differences between the prenatal diagnosis of valves (p> 0.065), pres-
ence of pre (p> 0.080) and post-surgery UTI (p> 0.085), number of surgeries (p> 0.100) and need
for transplantation.
CONCLUSIONS
The PUV represent a pathology that despite a prenatal diagnosis and correct surgical treatment can
evolve into renal failure and transplantation. Lower urinary tract dysfunction, vesicoureteral reflux,
and nadir creatinine are risk factors for renal failure.
16:03–16:08
S19-4 (LO)
BLADDER FUNCTION AT 5, 10 AND 15 YEARS
IN POSTERIOR URETHRAL VALVES (PUV)
Riccardo MANUELE
1
, Joanna CLOTHIER
1
, Anne WRIGHT
1
, Vanessa GUIDI
2
, Aurora
MARIANI
2
, Kalpana PATIL
2
, Arash TAGHIZADEH
2
and Massimo GARRIBOLI
2
1) Evelina London Children's Hospital, Paediatric Bladder Disorders, London, UNITED KINGDOM - 2) Evelina London
Children's Hospital, Paediatric Urology, London, UNITED KINGDOM
PURPOSE
Bladder function (BF) in PUV may vary with age. We studied evolution of BF through childhood.
MATERIAL AND METHODS
Retrospective cross-sectional review of non-invasive urodynamics at the age of 5, 10 and 15 years.
Data recorded: Bladder capacity (BC) classified as large, normal and small as per ICCS criteria
1
;
percentage ratio for BC and expected BC (EBC); uroflow, post-void residuals, lower urinary tract
symptoms (LUTS), current bladder treatment (anticholinergics, CIC).
Patients divided into 3 groups according to their age.
Statistical tests performed among the groups:
Anova to evaluate BC/EBC%.
Chi Square for uroflow, bladder emptying, LUTS, bladder treatment and any abnormal feature.
RESULTS
We analysed the studies performed in 133 children between 2008–2017; patients with renal trans-
plant (n = 25) and bladder augmentation (n = 13) were excluded.
BC/EBC% does not change through the years (p = 0.1128).
Outcomes of bladder function are similar in the three groups (table 1).