128
29
th
CONGRESS OF THE ESPU
S16: RENAL TRANSPLANTATION
Moderators: Wouter Feitz (Netherlands), Simona Gerocarni-Nappo (Italy)
ESPU Meeting on Friday 13, April 2018, 13:30–13:54
13:30–13:33
S16-1 (PP)
LONG-TERM OUTCOME OF PEDIATRIC RENAL
TRANSPLANT IN BOYS WITH POSTERIOR URETHRAL
VALVES (PUV)
Doris HEBENSTREIT
1
, Alexander SPRINGER
2
, Karin HEBENSTREIT
3
, Dagmar
CSAICSICH
4
, Thomas MÜLLER-SACHERER
4
and Gabriela BERLAKOVICH
5
1) Wilhelminenspital der Stadt Wien, Urology, Vienna, AUSTRIA - 2) AKH Vienna, Pediatric Surgery, Vienna, AUSTRIA -
3) Medical University of Vienna, Vienna, AUSTRIA - 4) AKH Vienna, Pediatric Nephrology and Gastroenterology, Vienna,
AUSTRIA - 5) AKH Vienna, Surgery, Vienna, AUSTRIA
PURPOSE
Posterior urethral valves (PUV) cause congenital lower urinary tract obstruction and in 30–50 %
leads to ESRD. There is conflicting data on outcome of renal transplantation (RT) in PUV. In this
study we sought to determine, whether there is a difference in the outcome of RT in PUV compared
to control group (NU).
MATERIAL AND METHODS
In this retrospective long-term study we analyzed possible factors that influence graft function
and graft survival. Between 1995 and 2016 there were 149 RT. There were 27 PUV patients, who
received 29 grafts. 30 control group patients received 31 renal grafts due to NU diagnosis.
RESULTS
There was no statistically significant disparity in graft function and estimated graft survival. Graft
failure occurred in 23.1 % of the PUV patients and 34.5 % patients in the NU group. In regression
analysis only age at transplantation and donor age had an impact on the renal function. There
was a higher incidence of UTI in the PUV group. Bladder dysfunction did not play a major role in
outcome. Vesicostomy was favorable to other forms of pretransplant intervention in regards of graft
function.
CONCLUSIONS
RT in PUV patients is successful with the same outcome as in NU patients. Good long-term out-
comes can be expected. Bladder dysfunction does not have a major impact on graft function and
survival in our cohort. It seems that the type of pre-transplant surgical procedures may influence
outcome and we recommend vesicostomy.