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11–14 APRIL, 2018, HELSINKI, FINLAND
08:29–08:32
S13-6 (PP)
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ASSESSMENT OF UROFLOWMETRY PARAMETERS
IN HEMATOPOIETIC CELL TRANSPLANTATION RECIPIENTS
COMPLICATED BY HEMORRHAGIC CYSTITIS
Sahar EFTEKHARZADEH
1
, Mehrnoosh SAMAEI
1
, Seyed Farshad SEYED TAHER
1
,
Amirali HAMIDIEH
1
and Abdol-Mohammad KAJBAFZADEH
2
1) Children's Hospital Medical Center, Tehran University of Medical Sciences, Pediatric Urology Research Center,
Tehran, ISLAMIC REPUBLIC OF IRAN - 2) Children's Hospital, Urology, Tehran, ISLAMIC REPUBLIC OF IRAN
PURPOSE
Hemorrhagic Cystitis (HC) constitutes a common yet serious complication in hematopoietic cell
transplantation (HCT) recipients; although preventive measures against HC are taken still it could
lead to severe morbidity and mortality in these patients. In this study we aim to assess value of
uroflowmetry parameters in prediction of HC occurrence.
MATERIAL AND METHODS
Thirty-seven patients with a mean±SD age of 9.98±3.77 years, who received HCT from July 2011 till
July 2015 were randomly included in this prospective study. Patients' uroflowmetry parameters
in the day of transplantation, 1 day after transplantation and 15 days after transplantation were
recorded. In case of accessibility uroflowmetry was performed at the time of HC as well.
RESULTS
Eighteen patients (48.6 %) faced HC 38.44±28.60 days following HCT. Uroflowmetry parameters
were compared among patients who suffered from HC and those who did not. Analysis of data
indicates that voided volume and average flow rate on the 15
th
days after transplantation were
significantly higher in patients who faced HC(p<0.05), also it indicates that distribution of voided
volume and average flow rate on the 15
th
days after transplantation differs significantly between
who suffered from HC and those who did not (p<0.05). Kendall's tau and Spearman's (rho) rank
correlation coefficient tests also indicate significant correlation between mentioned two parameters
and occurrence of cystitis (p<0.05).
CONCLUSIONS
This study suggests that uroflowmetry parameters could be valuable in predicting HC occurrence;
however, further studies with larger populations are needed to confirm its predictive values.